Learn more about GNS Healthcare by reading our publications, from our 2011 paper with Biogen Idec where we used REFS™ to identify new therapeutic targets for rheumatoid arthritis to our early work on the dynamics of cell signaling networks.
Causal modeling using network ensemble simulations of genetic and gene expression data predicts genes involved in rheumatoid arthritis. Xing H, McDonagh PD, Bienkowska J, Cashorali T, Runge K, Miller RE, Decaprio D, Church B, Roubenoff R, Khalil IG, Carulli J. PLoS Comput Biol. 2011. 7(3):e1001105.
Quantification and analysis of combination drug synergy in high-throughput transcriptome studies. Gümüs ZH, Siso-Nadal F, Gjrezi A, McDonagh P, Khalil I, Giannakakou P, Weinstein H. IEEE International Conference on Bioinformatics and Bioengineering, 2010. pp. 238-243.
The potential of biologic network models in understanding the etiopathogenesis of ovarian cancer. Khalil I, Brewer MA, Neyarapally T, Runowicz CD. Gynecol Oncol. 2010. 116(2):282-5.
Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP. Siso-Nadal F, Fox JJ, Laporte SA, Hébert TE, Swain PS. PLoS One. 2009. 4(10):e7189.
Customized care 2020: how medical sequencing and network biology will enable personalized medicine. Boguski MS, Arnaout R, Hill C. F1000 Biol Rep. 2009. 1:73.
Achieving confidence in mechanism for drug discovery and development. Pitluk Z, Khalil I. Drug Discov Today. 2007. 12(21-22):924-30.
A systems biology dynamical model of mammalian G1 cell cycle progression. Haberichter T, Mädge B, Christopher RA, Yoshioka N, Dhiman A, Miller R, Gendelman R, Aksenov SV, Khalil IG, Dowdy SF. Mol Syst Biol. 2007. 3:84.
An integrated approach for inference and mechanistic modeling for advancing drug development. Aksenov SV, Church B, Dhiman A, Georgieva A, Sarangapani R, Helmlinger G, Khalil IG. FEBS Lett. 2005. 579(8):1878-83.
Systems biology for cancer. Khalil IG, Hill C. Curr Opin Oncol. 2005. 17(1):44-8.
The statistical mechanics of complex signaling networks: nerve growth factor signaling. Brown KS, Hill CC, Calero GA, Myers CR, Lee KH, Sethna JP, Cerione RA. Phys Biol. 2004. 1(3-4):184-95.
Data-driven computer simulation of human cancer cell. Christopher R, Dhiman A, Fox J, Gendelman R, Haberitcher T, Kagle D, Spizz G, Khalil IG, Hill C. Ann N Y Acad Sci. 2004. 1020:132-53.